学术报告：（刘雳宇）Quantifying cancer cell collective behaviors in microfluidic governed landscapes
打印|关闭日期：2013-10-29 10:06:53阅读 次
Quantifying cancer cell collective behaviors in microfluidic governed landscapes
Liyu LIU (刘雳宇)
Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China
报告摘要: Cell invasion is a key process in cancer metastasis. The metastatic cancer cells invade the tissues by damaging the extracellular matrix (ECM). No single cell could finish this tough job and has the power of killing patients. We consider the cells’ invasion in a collective pattern that ultimately brings mass destruction to the ECM structures. Here we present our past effort in constructing microfluidic models to study cell invasion systematically and quantitatively. Our study shows that the cell invasion is sensitive to chemoattractant gradient and applies distant forces to the ECM. More importantly, the results reveal that the metastatic breast cancer cells MDA-MB-231 have cooperative behaviors that enhance their invasive efficiency. To further explore cell behaviors with different population and encountered ECM resistance, we are building micro tracks for cell invasion with patterned protein repellent coating (PRC). The latest result will be discussed in this talk.
报告人简介: Liyu LIU received his Ph.D degree from Physics at the Hong Kong University of Science and Technology in 2008. He then joined Robert Austin's group in Princeton University as a Postdoctoral Research Associate. He is now Professor in Institute of Physics, Chinese Academy of Sciences, awardee of the national young "one thousand" program and chief scientist of "973 program" (the National Basic Research Program). His current research focuses on constructing 3-D cancer cell metastasis models and study cell evolutions in complex landscapes.